Tragic Collision Claims Life of Melissa Guest in Middleburgh Crash on Route 145
MIDDLEBURGH, NY – The New York State Police have officially identified the victim of a devastating car crash that occurred in Middleburgh on the afternoon of July 29, 2025. The accident, which took place at approximately 1:30 p.m. along State Route 145 near Schoharie Hill Road, resulted in the death of 49-year-old Melissa Guest, a resident of Jefferson, New York.
According to initial reports released by State Police, the tragic incident happened when a car attempted to make a left turn onto Schoharie Hill Road from Route 145. As the vehicle was turning, it was struck on the passenger side by a second vehicle traveling northbound on Route 145. The force of the collision caused catastrophic damage, particularly to the side where Melissa Guest was seated.
Emergency responders arrived swiftly at the scene and made every effort to render aid. Despite their attempts, Melissa Guest sustained critical injuries and was pronounced dead at the scene. Her sudden loss has sent shockwaves through the Jefferson and Middleburgh communities, where she was known and loved by many.
The drivers of both involved vehicles, along with four passengers from the second car, were transported to Albany Medical Center. Authorities have confirmed that those individuals suffered non-life-threatening injuries, though they remain under observation as a precaution.
In the aftermath of the crash, a significant portion of Route 145 was closed for over four hours as law enforcement and accident reconstruction specialists worked to clear the scene and gather evidence. The closure caused notable traffic delays in the area, and the investigation into the cause of the crash is ongoing.
New York State Police have not released any information indicating that impairment, speed, or mechanical failure were factors in the collision, though they continue to collect witness statements and examine surveillance or dash cam footage, if available.
Melissa Guest’s death has left her family, friends, and neighbors grieving. Described as kind-hearted, community-oriented, and full of life, her absence will be deeply felt. In the coming days, loved ones are expected to gather for services to celebrate her life and mourn her passing.
This incident is a sobering reminder of how quickly lives can be changed or lost on the road. Authorities urge all drivers to remain cautious, especially at intersections—where some of the most serious crashes occur. Motorists are advised to remain vigilant, obey all traffic signals and signage, and allow extra time and distance when turning or merging in high-traffic areas.
The investigation into the July 29 crash remains active, and anyone with additional information is encouraged to contact the New York State Police. Updates will be provided as new details emerge.
In honor of Melissa Guest, the community will continue to rally around her loved ones during this unimaginably difficult time. Her memory will live on in the hearts of those who knew her and in the lasting impact she had on those around her.
